Yoichiro Iwakura Selected Research

Interleukin-1 (Interleukin 1)

1/2019	Uncoupling the Senescence-Associated Secretory Phenotype from Cell Cycle Exit via Interleukin-1 Inactivation Unveils Its Protumorigenic Role.
11/2018	Inhibition of interleukin-1 suppresses angiotensin II-induced aortic inflammation and aneurysm formation.
5/2017	Megakaryocytes compensate for Kit insufficiency in murine arthritis.
12/2015	Interdependence between Interleukin-1 and Tumor Necrosis Factor Regulates TNF-Dependent Control of Mycobacterium tuberculosis Infection.
4/2015	IL-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting IL-1 signal on macrophages.
5/2014	An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells.
1/2014	Persistent release of IL-1s from skin is associated with systemic cardio-vascular disease, emaciation and systemic amyloidosis: the potential of anti-IL-1 therapy for systemic inflammatory diseases.
1/2014	Rag2-deficient IL-1 Receptor Antagonist-deficient Mice Are a Novel Colitis Model in Which Innate Lymphoid Cell-derived IL-17 Is Involved in the Pathogenesis.
1/2014	Targeting IL-1β and IL-17A driven inflammation during influenza-induced exacerbations of chronic lung inflammation.
10/2013	Relative contribution of IL-1α, IL-1β and TNF to the host response to Mycobacterium tuberculosis and attenuated M. bovis BCG.

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Yoichiro Iwakura Research Topics

Disease

104	Inflammation (Inflammations) 05/2022 - 02/2003
79	Infections 01/2022 - 11/2001
40	Arthritis (Polyarthritis) 01/2021 - 02/2002
37	Neoplasms (Cancer) 01/2021 - 05/2002
24	Rheumatoid Arthritis 09/2015 - 02/2002
23	Colitis 01/2021 - 12/2002
16	Pneumonia (Pneumonitis) 01/2021 - 11/2001
16	Autoimmune Diseases (Autoimmune Disease) 01/2021 - 02/2006
11	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 08/2022 - 02/2006
11	Contact Dermatitis (Eczema, Contact) 01/2019 - 02/2003
11	Necrosis 11/2018 - 03/2002
11	Hypersensitivity (Allergy) 01/2018 - 09/2002
10	Dermatitis 05/2022 - 08/2010
10	Psoriasis (Pustulosis Palmaris et Plantaris) 11/2021 - 08/2010
10	Asthma (Bronchial Asthma) 01/2021 - 04/2003
9	Obesity 01/2022 - 09/2003
9	Carcinogenesis 01/2022 - 02/2007
8	Wounds and Injuries (Trauma) 01/2021 - 02/2004
8	Neoplasm Metastasis (Metastasis) 01/2021 - 01/2002
8	Reperfusion Injury 01/2019 - 09/2006
8	Mycoses (Diseases, Fungus) 08/2018 - 01/2007
8	Hyperplasia 01/2018 - 12/2004
8	Ischemia 10/2017 - 06/2002
8	Atherosclerosis 10/2013 - 04/2003
7	Virus Diseases (Viral Diseases) 01/2022 - 03/2002
7	Experimental Arthritis 12/2021 - 12/2003
7	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2021 - 05/2006
7	T-Cell Leukemia (Leukemia, T Cell) 03/2010 - 02/2002
6	Disease Progression 01/2016 - 01/2007
5	Fibrosis (Cirrhosis) 01/2021 - 12/2009
5	Melanoma (Melanoma, Malignant) 01/2019 - 05/2002
5	Communicable Diseases (Infectious Diseases) 01/2019 - 06/2005
5	Infarction (Infarctions) 03/2017 - 03/2003
5	Hepatitis 04/2014 - 07/2004
4	Skin Diseases (Skin Disease) 05/2022 - 09/2011
4	Porcine Reproductive and Respiratory Syndrome (PRRS) 01/2022 - 02/2011
4	Hypertension (High Blood Pressure) 01/2021 - 02/2010
4	Chronic Obstructive Pulmonary Disease (COPD) 01/2021 - 11/2002
4	Lung Diseases (Lung Disease) 12/2020 - 09/2008
4	Multiple Sclerosis 12/2018 - 07/2006
4	Pain (Aches) 08/2018 - 02/2006
4	Granuloma 04/2016 - 02/2007
4	Graft vs Host Disease (Graft-Versus-Host Disease) 05/2015 - 01/2009
4	Sepsis (Septicemia) 10/2014 - 06/2005
4	Hyperalgesia 01/2013 - 02/2006

Drug/Important Bio-Agent (IBA)

119	Interleukin-17 (Interleukin 17)IBA 08/2022 - 09/2002
93	CytokinesIBA 08/2022 - 11/2001
54	Interleukin-1 (Interleukin 1)IBA 01/2019 - 02/2002
32	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2021 - 06/2002
30	InterleukinsIBA 01/2021 - 11/2001
29	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 01/2021 - 08/2002
27	Interleukin-6 (Interleukin 6)IBA 10/2019 - 11/2001
21	Proteins (Proteins, Gene)FDA Link 11/2021 - 02/2003
21	Interleukin-23 (Interleukin 23)IBA 01/2018 - 04/2004
19	Interferon-gamma (Interferon, gamma)IBA 12/2017 - 11/2001
17	AntigensIBA 08/2022 - 01/2002
17	ChemokinesIBA 11/2021 - 09/2006
16	InflammasomesIBA 01/2021 - 08/2010
13	dectin 1IBA 01/2021 - 01/2007
13	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 01/2021 - 08/2003
12	LigandsIBA 01/2022 - 12/2004
12	Messenger RNA (mRNA)IBA 01/2013 - 10/2003
11	mouse dectin-2IBA 01/2021 - 05/2010
11	Interleukin-12 (IL 12)IBA 10/2013 - 05/2002
10	Interleukin-4 (Interleukin 4)IBA 01/2021 - 01/2002
10	InterferonsIBA 11/2011 - 11/2001
9	AntibodiesIBA 11/2021 - 10/2004
9	AutoantibodiesIBA 10/2017 - 03/2004
8	C-Type Lectins (C-Type Lectin)IBA 08/2022 - 02/2011
7	Monoclonal AntibodiesIBA 11/2021 - 04/2006
7	Dextrans (Dextran)FDA Link 01/2021 - 12/2008
7	Immunoglobulin G (IgG)IBA 01/2021 - 03/2002
7	GlucansIBA 01/2021 - 06/2011
7	Anti-Bacterial Agents (Antibiotics)IBA 10/2019 - 03/2004
7	Interleukin-1beta (Interleukin 1 beta)IBA 05/2009 - 03/2002
6	Interleukin-22 (IL-22)IBA 10/2019 - 03/2008
6	sodium sulfate (sodium bisulfate)FDA LinkGeneric 12/2018 - 12/2008
6	HaptensIBA 11/2018 - 02/2005
6	AllergensIBA 08/2014 - 02/2003
6	Interleukin-1alpha (Interleukin 1 alpha)IBA 12/2008 - 11/2002
5	Pattern Recognition ReceptorsIBA 01/2022 - 02/2011
5	VaccinesIBA 01/2021 - 03/2002
5	CollagenIBA 01/2021 - 02/2004
5	OvalbuminIBA 01/2021 - 12/2002
5	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2020 - 01/2004
5	Chemotactic FactorsIBA 11/2012 - 07/2004
5	Interleukin-18 (Interleukin 18)IBA 07/2012 - 05/2002
4	Therapeutic UsesIBA 05/2022 - 05/2002
4	MannansIBA 01/2022 - 05/2015
4	Polysaccharides (Glycans)IBA 12/2021 - 08/2014
4	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2021 - 05/2007
4	LipopolysaccharidesIBA 01/2021 - 11/2002
4	LipidsIBA 01/2021 - 05/2002
4	Imiquimod (Aldara)FDA LinkGeneric 10/2019 - 01/2017
4	Angiotensin IIIBA 11/2018 - 02/2010
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2018 - 02/2004
4	Pharmaceutical PreparationsIBA 01/2017 - 05/2002
4	Interleukin-17 ReceptorsIBA 03/2016 - 06/2009

Therapy/Procedure

17	Therapeutics 01/2020 - 02/2008
5	Transplantation 01/2017 - 08/2005